Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 47 0.0 0.468 0.03 0.085
biological_process el 47 0.09 0.971 0.673 0.28
biological_process ka 47 0.0 0.422 0.028 0.077
biological_process rf 47 0.0 0.468 0.03 0.085
cellular_component ct 47 0.0 0.558 0.048 0.101
cellular_component el 47 0.007 0.967 0.355 0.255
cellular_component ka 47 0.0 0.543 0.048 0.1
cellular_component rf 47 0.0 0.558 0.048 0.101
disease ct 12 0.001 0.825 0.181 0.251
disease el 12 0.214 0.827 0.552 0.19
disease ka 12 0.0 0.622 0.167 0.219
disease rf 12 0.001 0.824 0.181 0.251
genetic_interaction ct 43 0.0 0.991 0.376 0.329
genetic_interaction el 43 0.0 0.972 0.387 0.334
genetic_interaction ka 43 0.0 0.026 0.005 0.007
genetic_interaction rf 43 0.0 0.978 0.371 0.326
molecular_function ct 47 0.0 0.69 0.031 0.11
molecular_function el 47 0.047 0.991 0.458 0.232
molecular_function ka 47 0.0 0.567 0.026 0.092
molecular_function rf 47 0.0 0.69 0.029 0.107
pathway ct 25 0.0 0.996 0.061 0.194
pathway el 25 0.0 0.185 0.018 0.038
pathway ka 25 0.0 0.045 0.01 0.016
pathway rf 25 0.0 0.15 0.02 0.035
phenotype ct 13 0.0 0.936 0.317 0.33
phenotype el 13 0.016 0.88 0.52 0.275
phenotype ka 13 0.0 0.992 0.357 0.365
phenotype rf 13 0.0 0.929 0.316 0.329
protein_interaction ct 49 0.0 0.235 0.009 0.033
protein_interaction el 49 0.0 0.178 0.008 0.025
protein_interaction ka 49 0.0 0.012 0.001 0.003
protein_interaction rf 49 0.0 0.227 0.009 0.032

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 49 0.0 0.623 0.027 0.095
integration_mean_by_presence el 49 0.0 0.7 0.092 0.142
integration_mean_by_presence ka 49 0.0 0.733 0.021 0.103
integration_mean_by_presence rf 49 0.0 0.231 0.012 0.035
mean ct 49 0.0 0.501 0.016 0.075
mean el 49 0.0 0.497 0.042 0.09
mean ka 49 0.0 0.469 0.018 0.071
mean rf 49 0.0 0.246 0.02 0.057

CDF plots of non integrated kernels

CDF plots of integrated kernels